Table 3.
Biological activity of compounds 7–9 and 11 alone and with channel blockers tariquidar (T) and Ko143 (K) both at 10 µM
| Treatment | Decrease (%) in GSH/GSSG | Adult worm LD50 (μM) |
|---|---|---|
| 7 | 36.9 | 32.6 ± 0.26 |
| 7 + TK | 69.5 | 20.6 ± 0.31 |
| 8 | 11.7 | 22.3 ± 0.20 |
| 8 + TK | 66.9 | 14.7 ± 0.97 |
| 9 | 9 | >100 |
| 9 + TK | 17.5 | 47.6 ± 8.5 |
| 11 | 0.4 | No effect |
| 11 + TK | 5.8 | No effect |
| TK | 5.0 | No effect |
Adult worm data presented by three independent experiments as mean ± SD of biological replicates.
Source data are provided as a Source Data file.