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. 2023 Jun 22;14:3724. doi: 10.1038/s41467-023-39287-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Gene set enrichment analysis of secretome data ranked using a two-sided t-test from hypoxia-increased (blue) to hypoxia-decreased (green) in luminal-like (a, c, e, g) and basal-like (b, d, f, h) cell lines. The selected analyses show significant enrichment of KEGG pathways glycolysis, TCA cycle, oxidative phosphorylation and angiogenesis (GOID 1525) in the luminal-like hypoxic secretome. The basal-like hypoxic secretome was not enriched in either of the gene sets. Ranking the secretome data from basal-like (red) to luminal-like (blue) under normoxic (i) and hypoxic (j) conditions, showed an enrichment in angiogenic proteins in the basal-like subtype in both oxygen conditions. P-values were not adjusted for multiple testing. GSEA gene set enrichment analysis. RES running enrichment score. KEGG Kyoto Encyclopedia of Genes and Genomes. GO gene ontology analysis.