Fig. 5. Survival plots in breast cancer patients scored by 33P hypoxia stromal signature (METABRIC-Discovery cohort).

Kaplan–Meier of breast cancer specific survival in patients diagnosed with luminal-like and basal-like breast cancer (n = 852) (a), only luminal-like subtype (n = 734) (b), and only basal-like subtype (n = 118) (c) in the METABRIC-Discovery cohort. The patients are divided into quartiles depending on 33P signature score (33P-low, Q1 in blue; 33P-high, Q4 in red). The plots show a significant association between high 33P scores (Q4) and poor survival for patients diagnosed with luminal-like and basal-like breast cancer. Survival differences between groups were evaluated with a two-sided log-rank test.