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. 2023 Jun 22;14:3714. doi: 10.1038/s41467-023-39352-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Mean number of tissue-specific and variants detected in all tissues (common). b Mean relative distribution of distinct nucleotide conversions for tissue-specific and common SNVs. Tissue overlap represent variants that were common to all three tissues. c Allele frequency of tissue-specific T > C/A > G variants. N = 33 (heart), 32 (liver), 146 (tail). d Mean number of mismatches to the gRNA and PAM sequence in the area of ± 30 bases around the variant start site. Error bars depict the SEM in all panels. N = 3 mice in (a, b, d).