Table 2.

Optimizing the reaction conditions for the tandem oxidative amidation.

Entry	Solvent	Oxidant	Base	Amount of catalyst (mg)	Temperature (${}^{\circ }\mathrm{C}$)	Yielda (%)
1	CH3CN	TBHP	CaCO3	–	80	–
2	CH3CN	H2O2	CaCO3	–	80	–
3	CH3CN	–	CaCO3	10	80	–
4	CH3CN	TBHP	CaCO3	10	25	23
5	CH3CN	TBHP	CaCO3	10	60	47
6	CH3CN	TBHP	CaCO3	10	80	72
7	CH3CN	TBHP	CaCO3	20	80	89
8	CH3CN	TBHP	CaCO3	20	100	73
9	CH3CN	TBHP	CaCO3	30	80	89
10	CH3CN	TBHP	K2CO3	20	80	–
11	CH3CN	TBHP	Na2CO3	20	80	–
12	CH3CN	H2O2	CaCO3	20	80	32
13	CH3CN	O2	CaCO3	20	80	27
14	DMF	TBHP	CaCO3	20	80	52
15	DMSO	TBHP	CaCO3	20	80	67

Reaction conditions: benyzlamine hydrochloride (1.0 mmol), benzyl alcohol(1.5 mmol), catalyst, solvent (3.0 mL), base (1 mmol), oxidant(70 wt% in H₂O, 4 equiv), under N₂ atmosphere at 80 °C for 4 h.

^aThe yields relate to the isolated product.