Table 4.

Top CpG sites associated with the Braak stage

Chr	Pos	Probe	Islands name	Relationship to gene	Symbol	Beta (regression)	Δβ	p	BH	Rank (diff. analysis)
8	41,519,399	cg11823178		Body; TSS1500	ANK1; MIR486	0.124	0.031	2.2E-16	1.2E-12	1
8	41,519,308	cg05066959		Body; TSS1500	ANK1; MIR486	0.125	0.046	8.4E-16	2.2E-12	2
17	1,373,605	cg05417607	chr17:1,375,216–1,375,460	Body	MYO1C	0.103	0.023	3.1E-15	5.4E-12	7
3	188,664,632	cg12307200	chr3:188,665,275–188,665,552			− 0.068	− 0.024	9.6E-14	1.3E-10	5
8	119,122,430	cg05313153	chr8:119,123,974–119,124,432	1stExon	EXT1	0.054	0.023	4.8E-13	5.1E-10	3
21	47,855,893	cg23449541	chr21:47,855,892–47,856,143	Body	PCNT	0.069	0.025	4.7E-12	4.0E-09	15
15	74,836,094	cg19144497	chr15:74,833,241–74,833,961	5’UTR	ARID3B	0.056	0.033	5.9E-12	4.0E-09	16
6	106,041,074	cg23316191				0.047	0.022	6.1E-12	4.0E-09	429
10	77,188,318	cg18456331	chr10:77,191,061–77,191,571			0.080	0.021	2.4E-11	1.4E-08	145
17	6,616,653	cg16652063	chr17:6,616,422–6,617,471	5’UTR	SLC13A5	− 0.044	− 0.018	5.6E-11	3.0E-08	166
8	42,033,472	cg17693222		3’UTR	PLAT	0.039	0.013	8.8E-11	3.6E-08	4
1	47,066,498	cg23277659	chr1:47,069,615–47,070,179	Body	MKNK1	0.073	0.027	8.8E-11	3.6E-08	425
17	32,741,121	cg20942162				0.051	0.020	9.3E-11	3.6E-08	78
3	139,557,385	cg20865082				0.060	0.023	9.9E-11	3.6E-08	118
10	22,603,999	cg10713515	chr10:22,604,907–22,605,632	TSS1500	COMMD3	0.048	0.012	1.0E-10	3.6E-08	8
13	40,396,777	cg16042652				0.070	0.027	1.1E-10	3.6E-08	144
12	9,265,989	cg08300930		Body	A2M	0.042	0.022	1.2E-10	3.8E-08	184
10	73,472,315	cg07571519		3’UTR; Body	C10orf105; CDH23	0.048	0.019	1.4E-10	4.0E-08	22
10	112,260,509	cg02927679	chr10:112,257,163–112,258,684	Body	DUSP5	0.060	0.023	1.4E-10	4.0E-08	252
5	15,993,627	cg25579729				0.063	0.019	1.6E-10	4.1E-08	3