Table 1.
Characteristics of reports of acute renal failure involving CAR-T cells, and comparison between the three most frequently involved.
| Overall | Tisa-cel | Axi-cel | Brexu-cel | Fatal cases | |
|---|---|---|---|---|---|
| Number of reports (%) | 224 (100) | 108 (48.2) | 82 (36.6) | 17 (7.6) | 121 (54.0) |
| Male (%) | 137 (61.2) | 64 (61.0) | 43 (56.6) | 17 (100) | 71 (58.7) |
| Age (%) | |||||
| < 18 years | 36 (1.3) | 36 (33.3) | 0 | 0 | 24 (19.8) |
| 18–44 years | 28 (12.5) | 22 (20.4) | 5 (6.1) | 1 (5.9) | 18 (14.9) |
| 45–64 years | 66 (29.5) | 12 (11.1) | 38 (46.3) | 6 (35.3) | 30 (24.8) |
| 65–74 years | 47 (21.0) | 14 (13.0) | 24 (29.3) | 6 (35.3) | 25 (20.7) |
| ≥ 75 years | 20 (8.9) | 7 (6.5) | 7 (8.5) | 2 (11.8) | 10 (8.3) |
| Unknown | 27 (12.1) | 17 (15.7) | 8 (9.8) | 2 (11.8) | 14 (11.6) |
| Median age (IQR) | 60 (27–70) | 21 (12–62) | 64 (55–71) | 65 (56–73) | 55 (18–69) |
| Fatal cases (%) | 121 (54.0) | 69 (63.9) | 41 (50.0) | 5 (29.4) | 121 (100) |
IQR, interquartile range