Table 3.
Comparison between reports of acute renal failure involving CAR-T cells, with and without cytokine release syndrome (CRS)
| Overall | With CRS | Without CRS | |
|---|---|---|---|
| Number of reports (%) | 224 (100) | 154 (68.8) | 70 (31.3) |
| Male (%) | 137 (61.2) | 87 (58.4) | 50 (75.8) |
| Median age, years (IQR) | 60 (27–70) | 57 (20–70) | 60 (44–68) |
| Median time to onset, days | 7 (3–18) | 4 (3–8) | 15 (6–146) |
| Outcome | |||
| Fatal cases (%) | 121 (54.0) | 89 (57.8) | 32 (45.7) |
| Life-threatening reaction (%) | 64 (28.6) | 55 (35.7) | 9 (12.9) |
| Others (%) | 39 (17.4) | 10 (6.5) | 29 (41.4) |