Table 3:
HBsAg Loss at Week 240 by Participant Characteristics
| Subgroup (at randomization) | N (%) in the subgroup with HBsAg data available at week 240 | N (%) in the subgroup with HBsAg loss** | P value |
|---|---|---|---|
|
| |||
| Age Stratum (years) | 0·35 | ||
| 10-<30 | 27 (15·0) | 0 | |
| 30-<40 | 56 (31·1) | 3 (5·6) | |
| 40-<50 | 54 (30·0) | 2 (3·8) | |
| 50-<60 | 29 (16·1) | 2 (6·9) | |
| >60 | 14 (7·8) | 2 (16·7) | |
|
| |||
| Sex | 0·72 | ||
| Male | 117 (65·0) | 5 (4·3) | |
| Female | 63 (35·0) | 4 (6·3) | |
|
| |||
| Race | <0·001 | ||
| Asian | 146 (81·1) | 2 (1·4) | |
| Non-Asian | 34 (18·9) | 7 (20·6) | |
|
| |||
| HBeAg status | 0·032 | ||
| Negative | 87 (48·3) | 1 (1·1) | |
| Positive | 93 (51·7) | 8 (8·6) | |
|
| |||
| Genotype | <0·0001 | ||
| A1 | 10 (5·6) | 0 (0·.0) | |
| A2 | 12 (6·7) | 7 (58·3) | |
| B | 78 (43·3) | 1 (1·3) | |
| C | 59 (32·8) | 1 (1·7) | |
| D/E/F | 21 (11·7) | 0 (0·0) | |
|
| |||
| ALT (X ULN) * | 0·25 | ||
| <1ULN | 2 (1·1) | 0 (0.0) | |
| 1-<2 ULN | 43 (23·9) | 0 (0·0) | |
| 2-<5 ULN | 94 (52·2) | 8 (8·5) | |
| ≥5 ULN | 41 (22·8) | 1 (2·4) | |
|
| |||
| HBV DNA log10 IU/mL | 0·005 | ||
| ≤5 | 38 (21·1) | 1 (2·6) | |
| 5-8 | 90 (50·0) | 1 (1·1)> | |
| >8 | 52 (28·9) | 7 (13·5) | |
|
| |||
| qHBsAg log10 IU/mL | 0·008 | ||
| ≤3 | 42 (23·3) | 1 (2·4) | |
| 3-4 | 63 (35·0) | 0 (0·0) | |
| ≥4 | 75 (41·7) | 8 (10·7) | |
*
ALT ULN adjusted for sex (females 20-ULN and males 30-ULN)