Table 1.
Major studies for CNA in patients with vasovagal syncope
| Study | Study design | Number of patients | Age (y) | Follow-up duration (mo) | Technique | Results |
|---|---|---|---|---|---|---|
| LA (±RA) | ||||||
| Piotrowski et al, 202328 | RCT | 48 | 38 ± 10 | 24 | LA and RA EGM guided | Syncope in 8% in the CNA group, 54% in control group; improved QOL with CNA |
| Pachon et al, 201121 | Observational | 43 | 33 ± 15 | 45 ± 22 | LA, RA: Spectral and anatomic | 80% syncope free |
| Pachon et al, 202029 | Observational | 25 | 36 ± 19 | 24 | LA, RA: Spectral and anatomic | No recurrent syncope |
| Hu et al, 201911 | Observational | 115 | 43 ± 17 | 21 ± 13 | LA: Anatomic and HFS | 92% without recurrent syncope or presyncope |
| Aksu et al, 202010 | Observational | 51 | 36 ± 12 | 15 (8–29) | LA and RA: EGM and HFS | No recurrent syncope |
| Huang et al, 202030 | Observational | 49 | 42 ± 16 | 16 | RA and LA anatomic | 92% without recurrent syncope or presyncope |
| Xu et al, 202231 | Observational | 108 | 51 ± 15 | 8 | LA: anatomic and HFS | 84% syncope-free |
| Tung et al, 202232 | Observational (abstract) | 71 | 47 | 8.5 | LA/RA varied | 82% syncope-free |
| RA only | ||||||
| Debruyne et al, 202133 | Observational | 20 | 41 ± 19 | 6 | RA anatomic (with imaging) | 95% reduction in syncope burden |
| Calo et al, 202122 | Observational | 18 | 37 ± 11 | 34 ± 6 | RA anatomic and EGM | Recurrent syncope in 17% and 28% with only prodromal episodes |
| Candemir et al, 202234 | Observational | 23 | 41 ± 13 | 10 ± 2.9 | RA anatomic | 96% syncope-free |
Values are mean ± SD or median (interquartile range), unless otherwise indicated.
CNA = cardioneuroablation; EGM = electrogram; HFS = high-frequency stimulation; QOL = quality of life; RA = right atrium; RCT = randomized controlled trial.