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. 2023 Jun 22;6(9):e202302066. doi: 10.26508/lsa.202302066

Figure 7. CTPS1 is an essential gene for survival and proliferation of most cancer cell lines.

Figure 7.

Chronos score of 1,064 cell lines for CTPS1 and CTPS2, extracted from the DepMap 22Q1 Public + Score Chronos dataset. Counterselection of CRISPR-targeted cells leads to guide depletion and is translated by a negative score. A score of 0 corresponds to a non-essential gene, whereas a negative score shows a dependency for the concerned gene. The score of −1 corresponds to the median of all essential genes from the DepMap database. For this DepMap release: (44).