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. 2023 Jun 9;17:1180308. doi: 10.3389/fnins.2023.1180308

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Copyright © 2023 Noor, Pritha, Pasmay, Sanchez, Sanchez, Fernandez-Oropeza, Sun, Dell’Orco, Davies, Savage, Mellios and Milligan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PAE differentially modulates spinal circRNA expression following a minor nerve injury. (A) Volcano plots of differentially expressed circRNAs between nerve-injured PAE and Sac spinal cord, compared to their corresponding control tissues. X-axis represents log2 fold change (dotted line = 1.5-fold), Y-axis represents –log10 p-value (dotted line: p = 0.05). The red points in the plot represent the differentially expressed circRNAs, with 1.5-fold changes (p < 0.05). (B) The bar graphs represent the number of differentially expressed circRNAs as a result of injury, that are common or unique in PAE and Sac control rats. Among the altered circRNAs that are common in Sac control and PAE rats, the numbers of circRNAs that are further up or down-regulated in PAE conditions as a result of nerve injury are shown. (C) Ingenuity Pathway Analysis (IPA) from the host genes of the differentially expressed circRNAs is used to generate the list of associated diseases or functions (Y-axis) with associated −log p-values (X-axis).