Table 2.

Common canonical pathways associated with circRNA host genes in both PAE and Sac rats following minor nerve injury.

Ingenuity canonical pathways that are included in the top 50 pathways in both PAE and Sac rats	−log(p-value), minor nerve injury vs. sham surgery in PAE rats	−log(p-value), minor nerve injury vs. sham surgery in Sac rats
Synaptogenesis signaling pathway	16	9.58
Protein kinase A signaling	11.7	4.42
Opioid signaling pathway	10.1	4.53
Neuropathic pain signaling in dorsal horn neurons	6.05	3
Circadian rhythm signaling	9.14	2.76
cAMP-mediated signaling	6.7	3.04
Amyotrophic lateral sclerosis signaling	10.3	6.77
Gap junction signaling	4.64	4
TR/RXR activation	7.44	6.56
Dopamine-DARPP32 feedback in cAMP signaling	9.45	4.89
Insulin secretion signaling pathway	5.66	3.45
Calcium signaling	10.8	4.81
CLEAR signaling pathway	5.6	4.85
Glutamate receptor signaling	8.58	3.94
Myelination signaling pathway	5.35	3.1
Synaptic long-term potentiation	7.62	4.67
Autophagy	6.17	5.46
Adrenomedullin signaling pathway	4.17	3.5
Molecular mechanisms of cancer	5.64	4.39
NGF signaling	4.32	2.89
Oxytocin signaling pathway	5.29	3.63
IL-15 production	6.39	3.87
Sphingosine-1-phosphate signaling	4.32	3.42
PPARα/RXRα activation	4.32	6.23
Endocannabinoid neuronal synapse pathway	8.92	5.76
Synaptic long-term depression	7.05	2.66
Estrogen receptor signaling	6.9	4.85
Huntington’s disease signaling	5.67	4.46
Axonal guidance signaling	5.39	4.02
SNARE signaling pathway	5.06	3.41
RAR activation	4.8	4.78
Senescence pathway	4.36	2.9
Ephrin A signaling	4.29	3.62