Table 1. Meta-analyses of Depression Symptom Severity Stratified by Categorical Study-Level Characteristics.
| Variable | No. | SMD (95% CI) | I 2 | Test of interaction (P value) | ||
|---|---|---|---|---|---|---|
| Cohorts | Cancer | Control | ||||
| Overall | 21 | 6717 | 22 607 | 0.23 (0.09 to 0.37) | 92% | NA |
| Survivors, in remission | 16 | 6491 | 21 367 | 0.18 (0.02 to 0.33) | 93% | .13 |
| Undergoing or recent treatment | 5 | 226 | 1240 | 0.44 (0.13 to 0.74) | 76% | |
| Age at diagnosis <5 y | 2 | 510 | 2899 | −0.20 (−0.56 to 0.17) | 0 | .04 |
| Age at diagnosis between 5 and 12 y | 5 | 332 | 794 | 0.14 (−0.12 to 0.41) | 74% | |
| Age at diagnosis between 12 and 18 y | 1 | 56 | 391 | 0.61 (0.33 to 0.90) | NA | |
| Age at data collection between 5 and 12 y | 1 | 58 | 64 | 0.15 (0.75 to 0.46) | NA | .75 |
| Age at data collection between 12 and 18 y | 3 | 767 | 1075 | 0.23 (0.09 to 0.55) | 91% | |
| Age at data collection between 18 and 25 y | 7 | 1381 | 2163 | 0.12 (0.11 to 0.34) | 63% | |
| Age at data collection >25 y | 5 | 4385 | 9432 | 0.10 (0.15 to 0.34) | 92% | |
| Continent of study: Europe | 9 | 1102 | 2918 | 0.30 (0.06 to 0.53) | 93% | .87 |
| Continent of study: North America | 8 | 5362 | 17 757 | 0.41 (0.16 to 0.65) | 87% | |
| Continent of study: Asia | 3 | 235 | 1914 | 0.25 (−0.15 to 0.65) | 74% | |
| Compared with matched controls | 17 | 1702 | 13 349 | 0.12 (0.10 to 0.43) | 89% | .41 |
| Compared with siblings | 4 | 5015 | 9258 | 0.26 (0.17 to 0.42) | 94% | |
Abbreviations: NA, not applicable; SMD, standardized mean difference.