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. Author manuscript; available in PMC: 2023 Nov 1.
Published in final edited form as: Drug Alcohol Depend. 2022 Sep 20;240:109640. doi: 10.1016/j.drugalcdep.2022.109640

Fig. 3.

Fig. 3.

Repeated administration of Δ8-THC induces physical dependence. Mice were treated with Δ8-THC (1-50 mg/kg, s.c.) twice daily for 5 days. On the 6th day, mice received rimonabant (3 mg/kg, i.p.) and were observed for somatic signs of withdrawal: head twitches (A) and paw tremors (B) follow by struggling in the tail suspension test (C). Similarly, mice treated repeatedly with Δ8-THC (50 mg/kg, s.c.) displayed decreased marble burying (D) but no change in mobility (E). Data represent mean±SEM (n = 10[5m/5f]/group);*p<0.05, **p<0.005 v. vehicle.