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. Author manuscript; available in PMC: 2023 Nov 1.
Published in final edited form as: Drug Alcohol Depend. 2022 Sep 20;240:109640. doi: 10.1016/j.drugalcdep.2022.109640

Fig. 4.

Fig. 4.

Δ8-THC substitutes for Δ9-THC. Effects of vehicle, Δ9-THC and Δ8-THC on percentage of responses that occurred on the Δ9-THC-associated aperture (A-B) and response rate (C-D) in male (left panels) and female (right panels) mice trained to discriminate 5.6 mg/kg Δ9-THC from vehicle. Control tests with vehicle (V) and 5.6 mg/kg Δ9-THC (T) were conducted prior to each dose-effect curve, with results shown at the left side of the panels. Data represent mean±SEM (n = 13[5m/8f]/group except for % responding on the Δ9-THC-associated aperture for 30 mg/kg Δ8-THC where n = 10[4m/6f]). # indicate significant main effect for dose (as compared to vehicle) across both sexes (p<0.05).