Figure 3.

Degradation of subcutaneous microgel implants is directly proportional to the concentration of the EGBMA linker. a) Scheme of microgel fabrication with a near-infrared PEG linker and injection in a dorsal subcutaneous pocket. Representative images of implant pockets at different timepoints post-injection and after explant. b) Average normalized radiant efficiency for all formulations throughout the course of a month and after explant (points following vertical dashed line). c–e) quantification of normalized radiant efficiency at days 0, 9, and 25 post-implantation. All data presented as average ± s.d. minimum of n = 5 recipients for DTT, n = 10 for all other groups. P values calculated using one-way ANOVA with Dunnett multiple comparison analysis, **p < 0.05, ***p < 0.0005, ****p < 0.0001.