Table 1.
Baseline characteristics of study patients according to glycemic status.
| HbA1c | OGTT | |||||
|---|---|---|---|---|---|---|
| Normal | Prediabetes | p-value | Normal | Prediabetes | p-value | |
| n (%) | 535 (76%) | 167 (24%) | 194 (28%) | 508 (72%) | ||
| Demographics | ||||||
| Age, years | 62 + 10 | 66 + 8 | <0.0001 | 62 + 10 | 64 + 9 | 0.04 |
| Sex, male, n (%) | 278 (52%) | 70 (42%) | 0.02 | 62 (32%) | 286 (56%) | <0.0001 |
| Clinical characteristics | ||||||
| BMI, kg/m2 | 27 + 4 | 28 + 5 | 0.001 | 25 + 4 | 28 + 4 | <0.0001 |
| Systolic BP, mmHg | 143 + 23 | 144 + 19 | 0.53 | 141 + 20 | 144 + 23 | 0.1 |
| Diastolic BP, mmHg | 80 + 14 | 80 + 13 | 0.7 | 80 + 11 | 81 + 14 | 0.8 |
| Medications, n (%) | ||||||
| Antihypertensive | 181 (34%) | 64 (38%) | 0.3 | 63 (32%) | 182 (36%) | 0.4 |
| Lipid-lowering | 159 (30%) | 66 (40%) | 0.02 | 43 (22%) | 182 (36%) | 0.001 |
| Antianginal | 92 (17%) | 29 (17%) | 0.96 | 31 (16%) | 90 (18%) | 0.6 |
| Anginal symptoms, n (%) | 0.9 | 0.6 | ||||
| Non anginal-symptoms | 309 (58%) | 99 (60%) | 113 (59%) | 295 (58%) | ||
| Non-cardiac | 117 (22%) | 32 (19%) | 39 (21%) | 110 (22%) | ||
| Atypical angina | 58 (11%) | 20 (12%) | 25 (13%) | 53 (11%) | ||
| Typical angina | 45 (9%) | 15 (9%) | 13 (7%) | 47 (9%) | ||
| Smoking status, n (%) | 0.06 | 0.1 | ||||
| Active | 61 (11%) | 29 (17%)* | 21 (11%) | 69 (14%) | ||
| Never | 238 (44%) | 61 (37%) | 95 (49%) | 204 (40%)* | ||
| Past | 236 (44%) | 76 (46%) | 78 (40%) | 234 (46%) | ||
| Family history of CAD, n (%) | 177 (34%) | 56 (34%) | 0.9 | 65 (34%) | 168 (34%) | 0.9 |
| Biochemical profile | ||||||
| Cholesterol, mmol/L | 5.0 + 1.1 | 4.8 + 1.1 | 0.1 | 5.1 + 1.1 | 4.9 + 1.0 | 0.03 |
| LDL, mmol/L | 2.8 + 1.0 | 2.8 + 1.0 | 0.6 | 2.9 + 1.0 | 2.8 + 1.0 | 0.3 |
| HDL, mmol/L | 1.6 + 0.5 | 1.5 + 0.4 | 0.003 | 1.7 + 0.5 | 1.5 + 0.4 | <0.0001 |
| Triglycerides, mmol/L | 1.5 + 1.3 | 1.5 + 0.9 | 0.7 | 1.3 + 1.5 | 1.6 + 1.0 | 0.002 |
| Remnant cholesterol, mmol/L | 0.56 + 0.4 | 0.56 + 0.4 | 0.9 | 0.46 + 0.4 | 0.60 + 0.4 | <0.0001 |
| Creatinine, μmol/l | 77 + 15.6 | 77 + 15.4 | 0.9 | 75 + 16.3 | 78 + 15.1 | 0.01 |
| eGFR, ml/min/1.73 m2 | 81 + 9.9 | 78 + 11.5 | 0.001 | 81 + 10.5 | 81 + 10.4 | 0.7 |
| CRP, mg/L | 3.8 + 9.4 | 5.7 + 12.0 | 0.05 | 4.3 + 11.4 | 4.2 + 9.5 | 0.9 |
| Glycemic status | ||||||
| HbA1c, mmol/mol | 35 + 2.6 | 41 + 1.6 | <0.0001 | 35 + 3.4 | 37 + 3.3 | <0.0001 |
| FPG, mmol/L | 5.7 + 0.5 | 6.0 + 0.4 | <0.0001 | 5.2 + 0.2 | 6.0 + 0.4 | <0.0001 |
| 2h-PG, mmol/L | 6.4 + 1.6 | 7.3 + 1.8 | <0.0001 | 5.5 + 1.1 | 7.0 + 1.7 | <0.0001 |
| Glycemic classification, n (%) | ||||||
| IFG | 483 (69%) | |||||
| IGT | 156 (31%) | |||||
| PreDM by OGTT and HbA1c | 150 (30%) | |||||
Values are given as mean ± standard deviation (SD) or number and proportion (%).
*p < 0.05 compared with normal glycemic status.
HbA1c, Hemoglobin A1c; OGTT, Oral Glucose Tolerance Test; BMI, Body Mass Index; BP, Blood Pressure; CAD, Coronary Artery Disease; LDL, Low-Density Lipoprotein; HDL, High-Density Lipoprotein; eGFR, estimated Glomerular Filtration Rate; CRP, C-Reactive Protein; HbA1c, HemoglobinA1c; FPG, Fasting Plasma glucose; 2h-PG, 2 h plasma glucose; IFG, Impaired Fasting Glucose; IGT, Impaired Glucose Tolerance; DM, Diabetes Mellitus.