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. 2023 Mar 10;3(3):223–232. doi: 10.1021/acsbiomedchemau.3c00009

Figure 12.

Figure 12

(a) Design principle of activatable DNA aptamers to detect thrombin in blood clotting. (b) Representative PA images at 725 and 780 nm. (c) PA fold turn-on between thrombin-treated mice and PBS-treated mice. Adapted from ref (43). Copyright 2017 American Chemical Society. (d) Structure of HyP-1 and its turnover product. (e) Representative PA images of an ischemia mouse model and nonischemia control. (f) Quantified PA fold turn-on. Adapted with permission under a CCBY 4.0 license from ref (44). Copyright 2017 Springer Nature.