Table 1. Summary of Small Molecule Probes Highlighted in This Review Article.
| name | λabs | biomarker | disease model | mode of activation | delivery method | Author(s); year |
|---|---|---|---|---|---|---|
| PA-HD-H2O2 | 645 | H2O2 | mouse Alzheimer’s disease | uncapping | intravenous | Chan; 2021 |
| turnover | 745 | |||||
| RPS1 | 710 | Cu2+ | mouse Alzheimer’s disease | binding | intravenous | Sheng, Zhang; 2019 |
| CaSPA | 550 | Ca2+ | zebrafish neurostimulation | binding | intraventricular | Westmeyer; 2018 |
| PA-HD-MGL | 600 | MGL | mouse inflammation | uncapping | intraperitoneal | Chan; 2022 |
| turnover | 740 | |||||
| PA-HD-FAAH | 658 | FAAH | mouse inflammation | uncapping | intraperitoneal | Chan; 2022 |
| turnover | 730 | |||||
| APNO-5 | 764 | NO | mouse inflammation | uncapping | subcutaneous | Chan; 2018 |
| turnover | 673 | |||||
| SR-APNO-3 | 790 | NO | mouse flank tumor | uncapping | intratumoral | Chan; 2020 |
| turnover | 690 | |||||
| PACu-1 | 678 | Cu+ | mouse Wilson’s disease | uncapping | intraperitoneal | Chan; 2021 |
| turnover | 767 | |||||
| AP | 745 | O2•– | mouse liver injury | uncapping | intravenous | Ren, Yuan; 2022 |
| turnover | 835 | |||||
| DLP | 666 | DLP | mouse liver injury | uncapping | intravenous | Zeng, Wu; 2019 |
| turnover | 705 | |||||
| HyP-1 | 670 | hypoxia | mouse ischemic hypoxia | uncapping | intramuscular | Chan; 2017 |
| Red-Hyp-1 | 760 | |||||
| octaphyrin | 1200 | pH | mouse stomach pH | N/A | intragastric | Sarma, Sessler, Liu; 2021 |
| Cy7–1-maltotriose/hexose | 750 | maltodextrin transporter | mouse bacterial infections | N/A | intravenous | Gambhir; 2020 |
| Cy5.5 dimers | 680 | protease activity | mouse viral infection | N/A | subcutaneous | Jokerst; 2021 |