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Effect of zafirlukast analogues on TRADD-induced NF-κB activation. HEK293 cells transfected with luciferase reporter plasmids and TRADD plasmids and treated with increasing concentrations of zafirlukast analogues (0.01 to 500 nM). (A) NF-κB activity in TRADD expressing cells and (B) TRADD expressing cells treated with analogues. Data are means ± SD of three experiments.
