Fig. 5.

eIF4G1-mediated mitochondrial translation is required for learning and memory. The role of eIF4G1-mediated mRNA translation in cognitive function. Translation of mRNAs encoding mitochondrial ribosomes is selectively reduced in the brain of eIF4G1 haploinsufficient (eIF4G1-1D) mice. This leads to a decrease in mitochondrial translation and ATP production, which consequently result in diminished complexity of axonal arborization of hippocampal pyramidal neurons. The disruption of hippocampal neuron morphology interdicted hippocampus-dependent learning and memory tasks, such as the Morris water maze test.