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. 2023 Mar 30;3(3):192–203. doi: 10.1021/acsnanoscienceau.2c00062

Figure 2.

Figure 2

Intratumor injection of LNP loaded with OX-40 mRNA for enhanced cancer immunotherapy. Anti-OX40 antibody was proven to be effective in augmenting antitumor immunity in many kinds of cancers, which specifically bind with the costimulatory receptor OX40 on T cells and induce T cell immunity. To enhance the T cell response, LNP loaded with OX-40 mRNA was injected intratumorally, which induced the increased expression of OX40 receptors on T cells and burst the immunotherapy efficacy of the anti-OX40 antibody. Reprinted with permission under a Creative Commons CC BY License from ref (42). Copyright 2021 Springer Nature.