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. 2023 Mar 30;3(3):192–203. doi: 10.1021/acsnanoscienceau.2c00062

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© 2023 The Authors. Published by American Chemical Society

Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).

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Design of selective organ targeting (SORT) nanoparticles and their organ-specific targeting delivery after intravenous injection. Traditional four-component LNP with fixed ratios is proved to be mainly delivered to the liver, which is caused by the interactions between adsorbed ApoE on LNP and LDL receptors on hepatocytes. To realize organ-specific drug delivery, the fifth component SORT lipid (DOTAP, 18PA, DODAP) was added to the prescription of LNP. By changing the SORT lipid with different charges or adjusting the percent of SORT lipid, organ-specific systemic delivery of LNP can be realized. Briefly, cationic lipid (DOTAP), anionic lipid (18PA), and ionizable lipid (DODAP) help LNP target to lung, spleen, and liver, respectively. Reprinted with permission from ref (72). Copyright 2020 Springer Nature.