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. 2023 Mar 30;3(3):192–203. doi: 10.1021/acsnanoscienceau.2c00062

Figure 4.

Figure 4

Design of the bisphosphonate lipid (BP)-functionalized LNP targeting to bone microenvironment after systemic administration. BP contains two phosphate groups, which chelate calcium ions in the bone microenvironment and help the LNP delivered to the bone microenvironment after intravenous injection. This BP-LNP contained four lipids (BP-lipid, DOPE, cholesterol, and C14PEG2000), and was fabricated by a microfluidic device. Reprinted with permission from ref (76). Copyright 2022 American Chemical Society.