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. 2023 Mar 30;3(3):192–203. doi: 10.1021/acsnanoscienceau.2c00062

Figure 5.

Figure 5

Preparation of leukocyte-specific LNP. Unmodified LNP was first prepared by microfluidic mixing of lipids (1–4) and therapeutic mRNA (5). To anchor a leukocyte-specific ligand to LNP, ASSET micelle was mixed with LNP, which allows the further conjugation of anti-Ly6 antibody to the surface of LNP. ASSET is a modular targeting platform that bridges the LNP and specific antibodies to realize the construction of antibody-modified LNP. Adapted with permission under a Creative Commons CC BY License from ref (77). Copyright 2018 Springer Nature.