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. 2023 Mar 30;3(3):192–203. doi: 10.1021/acsnanoscienceau.2c00062

Figure 6.

Figure 6

Anti-CD5 antibody modified LNP for in vivo construction of CAR T cells specific to fibroblast activation protein (FAP), to trogocytose FAP from activated cardiac fibroblasts and improve cardiac function. Overexpressed FAP is considered a sign of cardiac injury. To reverse this injury, in vivo construction of FAPCAR T cell was reported, which was mediated by T cell-specific mRNA delivery. FAP CAR protein encoded by mRNA could be anchored to T cells to exert the anti-FAP activity. The T cell-targeted delivery of mRNA was realized by anti-CD5 antibody-modified LNP, in which the anti-CD5 antibody was chemically conjugated to the LNP surface after the LNP was prepared. Reprinted with permission from ref (83). Copyright 2022 The American Association for the Advancement of Science.