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. Author manuscript; available in PMC: 2023 Jun 23.
Published in final edited form as: J Clin Pathw. 2023;9(1):22–28. doi: 10.25270/jcp.2023.01.02

Table 2.

Proposed process for diagnosis of patients presenting with post–COVID-19 syndrome dyspnea or cough

I. Bedside tests
  1. Vital signs including pulse oximetry

  2. 12-lead (EKG) if not one on file since COVID-19

  3. Orthostatic measurement

  4. 6-minute walk test (when feasible)

II. Labs
  1. Complete blood count

  2. Complete metabolic panel

  3. High-sensitivity troponin

  4. BNP

III. Additional tests
  1. 2-view CXR
    1. If abnormal, then high-resolution noncontrast chest CT
  2. If hypoxemic, then full PFTs with lung volumes and diffusion capacity

  3. Ventilation/Perfusion scan if prior pulmonary embolism with residual dyspnea or significantly reduced diffusing capacity

  4. Consider pulmonary referral when worsening hypoxemia or dyspnea and when pulmonary fibrosis is detected

  5. TTE (if ↑ BNP/troponin or abnormal EKG)
    1. If abnormal TTE, then cardiology consult
  6. If arrhythmia on EKG, order Holter monitor
    1. If abnormal, then cardiology e-consult
  7. If troponin abnormal → Cardiology consult (TTE with possible CMR)

  8. If exertional chest pain or EKG ischemic changes, consider further cardiac testing

Abbreviations: BNP, B-natriuretic peptide; CMR, cardiovascular magnetic resonance imaging; CT, computed tomography; CXR, chest x-ray; EKG, electrocardiogram; PFT, pulmonary function test; TTE, transthoracic echocardiogram.