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. 2023 Jun 23;22:99. doi: 10.1186/s12943-023-01791-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Construction of a global single-cell landscape of primary and metastatic LUAD. A Multiplex immunofluorescence map demonstrating CD34 expression in primary and metastatic LUAD tissues. Bar, 50 μm. B Flow chart of this study. The global single-cell landscape of primary and metastatic LUAD was constructed based on single-cell technology. C The single-cell atlas mapping cell types. D Bubble map showing cell marker genes for cell annotations. E Heat map showing copy number variation results to further validate the accuracy of cell annotation in the presence of multi-copy or low-copy number events in LUAD cells. F The difference in cell abundance between control, primary and metastatic LUAD