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. 2023 Jun 23;22:99. doi: 10.1186/s12943-023-01791-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Clonal evolutionary trajectory of metastatic LUAD cells. A The single cell atlas showing tumor cell subpopulations. B Dotted line graph showing the ratio of distinct tumor cell subpopulations in control, primary and metastatic LUAD. C The single-cell atlas mapping the expression of FAM83A and IGF2BP2 in tumor cells. D Fluorescence assay-fluorescent probe assay showing IGF2BP2 in LUAD tissues with high or low CD34 expression. Bar, 50 μm. E Volcano map showing differentially expressed genes in malignant cells and their subpopulations between metastatic and primary LUAD. F The single-cell atlas mapping the pseudotime values and evolutionary trajectory. G Evolutionary tree showing the evolutionary trajectory of tumor cells. H Heat map-pathway showing signaling pathways involved in temporally relevant genes