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. 2023 Jun 23;22:99. doi: 10.1186/s12943-023-01791-1

Fig. 3.

Fig. 3

Endothelial cell landscape in metastatic LUAD. A The single-cell atlas showing endothelial cell subpopulations. B Dotted line graph showing changes in abundance of endothelial cell subpopulations in control, primary and metastatic LUAD. C The single-cell atlas mapping the expression of IGF2BP2 in endothelial cells. D Immunofluorescence assay-fluorescent probe assay showing IGF2BP2 expression in endothelial cell subpopulations with high and low CD34 expression. Bar, 50 μm. E Shared markers of specific cell subpopulations (LUAD_IGF2BP2 and En_IGF2BP2). F Cluster-bubble plots demonstrating biological functions shared by specific cell subpopulations. G Cluster-bubble plots demonstrating KEGG pathways shared by specific cell subpopulations. H GSEA plots demonstrating the significant activation of biological signals related to secretion, secretion and synthesis of vesicles and phagocytosis of contents diffusion in specific cell subpopulations En_IGF2BP2 (left) and LUAD_IGF2BP2 (right)