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. 2023 Jun 22;23:223. doi: 10.1186/s12890-023-02512-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Comparation of predictive powers of 20-gene mutation signature with TMB level. (A) PFS levels of the NSCLC patients with high (≥ 10) and low (< 10) TMB values. (B) OS levels of the NSCLC patients with high (≥ 10) and low (< 10) TMB values. (C) PFS levels in the ICI treated NSCLC patients with TMB-H (≥ 10) and TMB-L (< 10) further stratified according to groups with high mutation signature (HM) or with no high mutation signature (NHM). (D) OS levels in the ICI treated NSCLC patients with TMB-H (≥ 10) and TMB-L (< 10) further stratified according to groups with high mutation signature (HM) or with no high mutation signature (NHM). (E) TMB levels in NSCLC patients [MSKCC, J Clin Oncol 2018] with different mutation signatures. (F) TMB levels in NSCLC patients [MSKCC, Nat Genet 2019] with different mutation signatures.P-values calculated by use of log-rank test (A,B,C,D) or unpaired t-test (E, F)