Table 1.
E3 ubiquitin ligases regulate osteoarthritis development and progression.
| Name | Targets | Functions | Ref |
|---|---|---|---|
| WWP1 | N/A | Involves in osteoarthritis development | (39) |
| WWP2 | Runx2 | Modulates osteoarthritis | (40) |
| Smurf1 | N/A | Regulates osteoarthritis | (41) |
| Smurf2 | SIRT1 | Regulates apoptosis, proliferation, inflammation in osteoarthritis chondrocytes | (42) |
| ITCH | JAG1 | Regulates chondrocyte damage and cartilage damage | (43) |
| FBXW7 | MKK7 | Regulates chondrocyte degeneration and osteoarthritis | (44) |
| FBXO3 | IL-18, IL-1β, pyroptosis-related proteins | Regulates knee osteoarthritis | (45) |
| FBXO6 | MMP14 | Controls post-injury osteoarthritis development | (46) |
| FBXO21 | ERK | Regulates osteoarthritis-associated cartilage degeneration | (47) |
| HECTD1 | Rubicon | Controls stress-induced chondrocyte death and osteoarthritis | (48) |
| Cbl-b | TrkA | Regulates osteoarthritis pain | (49) |
| UFL1 | NO, PGE2, iNOS, COX-2, MMP-3, MMP-13, ADAMTS-4, ADAMTS-5 | Involves in osteoarthritis development | (50) |
| HRD1 | OS9 | Regulates osteoarthritis development | (51) |