Table 2.

USP regulate osteoarthritis progression.

Name	Targets	Functions	Ref
USP3	SIRT3	Reduces chondrocyte senescence	(98)
USP5	TRAF6	Promotes proinflammatory cytokine production	(99)
USP7	NOX4, SOX9	Controls osteoarthritis progression	(100, 101)
USP13	PTEN/AKT	Inhibits osteoclastogenesis, synovial hyperplasia, cartilage damage, inflammation	(102)
USP14	IκBα	Influences chondrocyte dedifferentiation	(103)
USP15	ERK2	Suppresses osteoarthritis progression	(104)
USP49	Axin	Regulates chondrocyte apoptosis	(105)