Table 2.
Univariate Cox analysis of PFS or OS by the levels of circulating cytokines in NSCLC patients who received immunotherapy.
| Cytokine | PFS | OS | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| CCL5 | ||||
| Top 1/3 vs. Bottom 2/3 | 1.24 (0.73-2.10) | 0.434 | 0.78 (0.32-1.92) | 0.585 |
| ICAM-1 | ||||
| Top 1/3 vs. Bottom 2/3 | 1.57 (0.94-2.62) | 0.086 | 0.8 (0.33-1.96) | 0.625 |
| serpinE1 | ||||
| Top 1/3 vs. Bottom 2/3 | 1.46 (0.86-2.50) | 0.160 | 0.95 (0.38-2.36) | 0.913 |
| MIF | ||||
| Top 1/3 vs. Bottom 2/3 | 1.62 (1.00-2.61) | 0.046 | 1.03 (0.53-2.00) | 0.934 |
| CXCL12 | ||||
| Top 1/3 vs. Bottom 2/3 | 2.50 (1.55-4.04) | 1e-04 | 2.31(1.22-4.36) | 0.008 |
| Complement C5 | ||||
| Top 1/3 vs. Bottom 2/3 | 0.94 (0.57-1.55) | 0.807 | 1.22 (0.65-2.30) | 0.537 |
| IL-18 | ||||
| Top 1/3 vs. Bottom 2/3 | 1.31 (0.79-2.18) | 0.292 | 0.946 (0.43-2.08) | 0.890 |
The bold values means p < 0.05.