Table 3.

Multivariate Cox analysis of PFS or OS by clinical parameters, PD-L1 status and CXCL12 level.

Factor	PFS		OS
	p value	HR (95% CI)	p value	HR (95% CI)
PD_L1 TPS ≥1% vs. <1%	0.003	0.48 (0.29-0.78)	0.247	0.68 (0.36-1.30)
Liver Metastasis Yes vs. No	0.025	2.17 (1.10-4.29)	0.043	2.24 (1.03-4.90)
irAEs Yes vs. No	0.001	0.39 (0.22-0.69)	0.046	0.41 (0.17-0.98)
CXCL12 Top 1/3 vs. Bottom 2/3	4e-04	3.01 (1.63-5.55)	0.001	4.63 (1.81-11.80)
MIF Top 1/3 vs. Bottom 2/3	0.915	1.03 (0.56-1.90)	0.079	0.42 (0.16-1.10)

irAE, immune-related adverse events; TPS, tumor proportion score; CI, confidence interval; HR, hazard ratio; the bold values, p < 0.