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. 2023 Jun 9;14:1186224. doi: 10.3389/fimmu.2023.1186224

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Copyright © 2023 Capelli, Cuofano, Pavoni, Frigerio, Lisini, Nava, Quaroni, Colombo, Galli, Bezukladova, Panina-Bordignon, Gaipa, Comoli, Cossu, Martino, Biondi, Introna and Golay

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation between CAR expression and the cytotoxic potential of CARCIK-CD19 cells. CARCIK-CD19 cells expanded for clinical use of validation purposes, using the same GMP standard operating procedure, in 2 different Cell Factories (Center of Cellular Therapy “G. Lanzani, Bergamo and Laboratory of Cell and Gene Therapy Stefano Verri, Monza, Italy), in the context of common clinical trials (NCT03389035 and NCT05252403), were tested for percentage of CAR-CD19 expression and cytotoxic activity against the REH leukemic cell line, using the same assays conditions (N=60). Percentage CAR expression correlated significantly with percentage cytotoxicity (potency) (The Pearson correlation coefficient R=0,64, p<0.0001).