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. Author manuscript; available in PMC: 2023 Jun 23.
Published in final edited form as: ACS Chem Neurosci. 2020 Oct 7;11(20):3245–3258. doi: 10.1021/acschemneuro.0c00372

Figure 9.

Figure 9.

Virtual DDI studies between acetaminophen and fentanyl. (a) Systemic plasma concentration of fentanyl over time with and without 4000 mg of acetaminophen. (b) Trial arithmetic mean and standard deviation for 10 groups of 10 individuals out of a population of 100 for a fentanyl PK profile simulation with and without 4000 mg of acetaminophen. (c) Systemic plasma concentration of fentanyl over time with and without 80000 mg of acetaminophen. (d) Trial arithmetic mean and standard deviation for 10 groups of 10 individuals out of a population of 100 for a fentanyl PK profile simulation with and without 80000 mg of acetaminophen.