Figure 1.
Akkermansia muciniphila protected against NASH in high-fat-diet mice. The body weight (a) and food intake (b) of mice were recorded. The blood glucose levels (c) and area under the curve (AUC) of the glucose tolerance test (GTT) at the 11th week (d) were recorded. The levels of fasting glucose (e) and TC (f) in serum were examined by biochemical tests at 18 weeks. (g-i) the levels of serum ALT and AST were measured at 8, 12, 16, 18 and 20 weeks. Data are shown as the mean ± SEM or the median with interquartile range. (j) Representative images of hepatic hematoxylin & eosin (H&E) staining. Scale bar, ×200 (left), ×400 (right). The blue arrows indicate the steatohepatitis foci of inflammation with clusters of inflammatory cells. (k) Liver NAFLD activity score (NAS) ratio. n = 8 mice/group. p values were determined using one-way ANOVA or the Kruskal‒Wallis test. *p < 0.05, **p < 0.01, ***p < 0.001. Groups: NC, normal chow control; HFD, high-fat diet; HFD + AKK, high-fat diet and oral treatment with Akkermansia muciniphila.