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. 2023 Jun 9;14:1174116. doi: 10.3389/fneur.2023.1174116

Table 2.

Neurologic clinical manifestations.

Neurological symptoms n = 45 %
Paresthesia 40 88.9
Numbness 39 86.7
Dizziness 39 86.7
Headache 36 80
Subjective cognitive decline 31 68.9
Subjective weakness 25 55.6
Imbalance 19 42.2
Neurological conditions diagnosed n = 45 %
Peripheral neuropathya 39 86.7
Small fiber neuropathyb 8 17.8
Dysautonomiac 10 22.2
Cognitive impairmentd 12 26.7
Trigeminal neuralgia 3 6.7
Electroencephalogram abnormalitye 2 4.4
Myelopathyf 1 2.2
Transient ischemic attackg 1 2.2
a

Six patients had sensorimotor neuropathy and 33 had sensory neuropathy.

b

Six patients showed positive skin biopsy. One patient was diagnosed based on clinical symptoms, evidence of small fiber neuropathy on a quantitative sensory test, and a normal nerve conduction test. One patient was diagnosed based on clinical symptoms, sudomotor dysfunction on autonomic tests, and a normal nerve conduction test.

c

Ten patients were diagnosed using an autonomic test.

d

Montreal Cognitive Assessment (MoCA) score ≤ 25/30. Of the 45 patients included in this study, 22 underwent MoCA testing.

e

One patient had intermittent irregular delta activity in the left anterior-midtemporal region. One patient had intermittent focal theta to delta slowing in the left frontotemporal region.

f

Cervical myelopathy with position sense loss.

g

Likely due to a hypercoagulable state of unknown origin.