TABLE 1.
The Distribution of Symptoms, Clinical Follow-up, and Cohort Evolution of 62 Pediatric Patients Undergoing Cancer Treatment with Detectable SARS-CoV-2 by RT-PCR Between March 01, 2020, and November 30, 2021, Followed up at the Pediatric Oncology Division at IMIP
| Variables | All Patients | March to December 2020 | January to October 2021 | ||
|---|---|---|---|---|---|
| n (%) | n = 50 | (%) | n = 12 | (%) | |
| Asymptomatic patients—systematic search | 12 (19.3) | 10 | (20.0) | 2 | (16.7) |
| Signs and symptoms during treatment for COVID-19 | 50 (80.6) | 40 | (80.0) | 10 | (83.3) |
| ▪ Fever | 36 (58.0) | 29 | (58.0) | 7 | (58.3) |
| ▪ Coryza | 19 (30.6) | 13 | (26.0) | 6 | (50.0) |
| ▪ Cough | 16 (25.8) | 13 | (26.0) | 3 | (25.0) |
| ▪ Dyspnea | 13 (21.0) | 10 | (20.0) | 3 | (25.0) |
| ▪ Nausea/vomits | 3 (4.8) | 2 | (4.0) | 1 | (8.3) |
| ▪ Diarrhea | 9 (14.5) | 8 | (16.0) | 1 | (8.3) |
| ▪ Headache | 5 (8.0) | 4 | (8.0) | 1 | (8.3) |
| ▪ Anosmia | 4 (6.4) | 4 | (8.0) | 0 | (0) |
| Follow-up | |||||
| ▪ Outpatients | 21 (33.9) | 16 | (32.0) | 5 | (41.7) |
| ▪ Hospitalization | 41 (66.1) | 34 | (68.0) | 7 | (58.3) |
| ICU | 12 (19.3) | 9 | (18.0) | 3 | (25.0) |
| History of COVID at home | 15 (24.2) | 9 | (18.0) | 6 | (50.0) |
| Complementary exams | |||||
| Changes in chest imagining exams (radiograph or CT) | 18 (29.0) | 13 | (26.0) | 5 | (41.7) |
| Lymphopenia (<300 cells/mm³) | 21 (33.9) | 17 | (34.0) | 4 | (33.3) |
| Neutropenia (<500 cells/mm³) | 31 (50.0) | 25 | (50.0) | 6 | (50.0) |
| Kidney changes | 6 (9.7) | 5 | (10.0) | 1 | (8.3) |
| Classification of severity (Dong et al.,2020) | |||||
| ▪ Mild/moderate | 47 (75.8) | 38 | (76.0) | 9 | (75.0) |
| Severe/critical COVID-19 | 15 (24.2) | 12 | (24.0) | 3 | (25.0) |
| MIS-C (Panigrahy et al., 2020) | 8 (12.9) | 6 | (12.0) | 2 | (16.6) |
| Treatment | |||||
| Respiratory support | 11 (17.7) | 9 | (18.0) | 2 | (16.6) |
| ▪ Mechanical ventilation | 6 (9.7) | 4 | (8.0) | 2 | (16.6) |
| Vasoactive drugs | 6 (9.7) | 4 | (8.0) | 2 | (16.6) |
| Death during hospitalization | 6 (9.7) | 4 | (8.0) | 2 | (16.6) |
| ▪ Cause of death ▪ severe acute respiratory syndrome ▪ Fungic infection | 6 (9.7) 5 (8.0) (1.6) | 3 1 | (6) (2) | 2 0 | (16.6) (0) |
COVID-19 indicates coronavirus disease 2019; ICU, intensive care unit.