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. 2023 Jun 8;14(12):2320–2332. doi: 10.1021/acschemneuro.3c00069

Figure 6.

Figure 6

Analysis of DNA methylation measured by pyrophosphate sequencing in CpG island 2 of the BDNF gene promoter. (A) Representative pyrophosphate sequencing analysis of control, hypoxia, and HPC groups. (B) Global DNA methylation of CpG island 2 in the different groups. (C) DNA methylation at seven sites of CpG island 2 in control, hypoxia, and HPC groups. Before and after 5-Aza treatment, the DNA methylation at seven sites of CpG island 2 in the control group (D), hypoxia group (E), and HPC group (F). The data are presented as mean ± SEM, n = 3 for each group. Compared with the control group: *P < 0.05. Compared with the hypoxia group: #P < 0.05. Compared with the HPC group: &P < 0.05.