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. 2023 May 25;54(7):1875–1887. doi: 10.1161/STROKEAHA.123.042755

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© 2023 The Authors.

Stroke is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 5. — Stroke reduces gut short-chain fatty acid (SCFA). Feces were collected from the same mice before and after sham operation or ischemia, or twice in controls with 2 d difference. At day 2, mice were euthanized and the content of the cecum was collected. SCFAs were analyzed by gas chromatography–mass spectrometry. Ischemia (n=25) reduced the content of butyrate (*** P=0.0003), propionate (****P<0.0001), and acetate (***P=0.0006) in the feces vs the content before ischemia in the same mice (Wilcoxon matched-pairs signed rank test). Differences between values obtained before and after sham operation (n=7) and between the 2 control samples (n=11) were not significant so both groups were pooled together. In the cecum, the content of butyrate (*P=0.0357) and propionate (*P=0.174) was smaller in ischemic mice (n=14) vs sham/control mice (n=13; Mann-Whitney U test). Data are presented as violin plots showing all points and lines at the median and quartiles (dashed lines).