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. 2023 Jun 23;18(6):e0286454. doi: 10.1371/journal.pone.0286454

Fig 5. ABGE induces Mcl-1 degradation.

Fig 5

ABGE +venetoclax induced significantly higher levels of apoptosis than ABGE or venetoclax alone in MCF-7 and MDA-MB-361 cells. (a),Mitochondrial ROS and Intracellular ROS levels were detected by flow cytometry. (b),Cells proliferation were detected by MTT Assay. (c),The combination of ABGE and venetoclax led to the greatest percentage of Annexin-V-FITC-positive cells, and the percentage was significantly different from that of NC, ABGE-treated and venetoclax-treated cells for both cell lines. *indicates p value less than 0.05, **/**** indicates p value less than 0.01.