Table 2. Comparison of the effects of Metformin and TZDs on insulin sensitivity assessed with QUICKI.

Pavo et al.,2003 [9], Schernthaner et al.,2004 [10], Fidan et al.,2011 [11], Chu et al.,2002 [12], Hällsten et al.,2002 [13], Kautzky-Willer et al.,2005 [14], Tiikkainen et al.,2004 [15], Ceriello et al.,2005 [16], Roden et al.,2005 [17]

 

Author ID	Metformin		TZDs
	QUCKI at Baseline	QUICKI at endpoint	QUCKI at Baseline	QUICKI at endpoint
Chu et al.,2002 [12]	0.256	0.269	0.257	0.277
Fidan et al.,2011 [11]	0.306	0.319	0.306	0.329
Hallsten et al.,2002 [13]	0.310	0.330	0.328	0.344
Kautzky-Willer et al.,2005 [14]	0.294	0.313	0.298	0.319
Pavo et al.,2003 [9]	0.278	0.289	0.287	0.307
Schernthaner et al.,2004 [10]	0.289	0.298	0.288	0.304
Ceriello et al.,2005 [16]	0.290	0.301	0.294	0.311
Tiikkainen et al.,2004 [15]	0.301	0.325	0.304	0.329
Roden et al.,2005 [17]	0.304	0.315	0.303	0.321
Average (mean ± SD)	0.292 ± 0.017	0.306 ± 0.019	0.296 ± 0.019	0.316 ± 0.019
Significance (p-value)	P < 0.00001		P < 0.00001
Overall significance between Metformin and TZDs endpoints	P = 0.0003