Table 2.
Analytical features for hallucinogen determination in oral fluids by MEPS and LC–MS/MS
| Analyte | R2 | LOD (µg L−1) | LOQ (µg L−1) | RSD (%) | Recovery (% ± s, n = 3) | ||
|---|---|---|---|---|---|---|---|
| 20 μg L−1 | 50 μg L−1 | 100 μg L−1 | |||||
| 2C-C | 0.998 | 0.80 | 2.66 | 6.2 | 108 ± 3 | 85 ± 2 | 104 ± 2 |
| DOC | 0.993 | 1.22 | 4.06 | 9.3 | 123 ± 5 | 98 ± 4 | 105 ± 3 |
| 2C-E | 0.992 | 0.34 | 1.12 | 2.3 | 123 ± 2 | 105 ± 4 | 119 ± 3 |
| LSD | 0.997 | 0.74 | 2.47 | 5.3 | 129 ± 5 | 108 ± 3 | 118 ± 6 |
| Mescaline-NBOMe | 0.990 | 0.78 | 2.61 | 5.4 | 126 ± 5 | 120 ± 4 | 118 ± 4 |
| 3,4-DMA-NBOMe | 0.993 | 0.21 | 0.69 | 2.8 | 127 ± 1 | 123 ± 2 | 118 ± 2 |
| DOI | 0.990 | 0.58 | 1.94 | 4.3 | 113 ± 6 | 103 ± 8 | 118 ± 3 |
| 2C-P | 0.990 | 0.90 | 2.99 | 6.5 | 117 ± 6 | 104 ± 3 | 116 ± 2 |
| 25H-NBOMe | 0.991 | 0.27 | 0.88 | 1.8 | 124 ± 6 | 104 ± 9 | 119 ± 2 |
| 25N-NBOMe | 0.994 | 0.29 | 0.96 | 4.7 | 129 ± 5 | 111 ± 2 | 119 ± 6 |
| 25C-NBOH | 0.998 | 0.44 | 1.45 | 5.0 | 112 ± 6 | 106 ± 2 | 109 ± 4 |
| 25-MMA-NBOMe | 0.993 | 1.16 | 3.85 | 8.0 | 124 ± 3 | 106 ± 4 | 121 ± 2 |
| 4-MA-NBOMe | 0.993 | 0.24 | 0.81 | 3.4 | 119 ± 4 | 105 ± 4 | 105 ± 4 |
| 25C-NBF | 0.996 | 0.09 | 0.29 | 0.9 | 108 ± 5 | 102 ± 4 | 104 ± 3 |
| 25B-NBOH | 0.995 | 0.41 | 1.36 | 3.1 | 124 ± 4 | 102 ± 2 | 111 ± 2 |
| 30C-NBOMe | 0.996 | 0.25 | 0.84 | 3.4 | 80 ± 7 | 110 ± 3 | 121 ± 1 |
| 25B-NBF | 0.996 | 0.87 | 2.89 | 6.1 | 95 ± 8 | 103 ± 8 | 113 ± 2 |
| 25D-NBOMe | 0.993 | 0.29 | 0.96 | 2.0 | 121 ± 5 | 113 ± 2 | 119 ± 6 |
| 25C-NBOMe | 0.994 | 0.64 | 2.14 | 4.3 | 122 ± 5 | 119 ± 4 | 115 ± 9 |
| 25 T-NBOMe | 0.993 | 0.67 | 2.23 | 4.8 | 125 ± 4 | 115 ± 3 | 123 ± 4 |
| 25I-NBOH | 0.997 | 0.32 | 1.07 | 3.7 | 90 ± 10 | 109 ± 1 | 115 ± 2 |
| 4EA-NBOMe | 0.991 | 0.27 | 0.89 | 1.9 | 108 ± 8 | 100 ± 2 | 114 ± 3 |
| 25B-NBOMe | 0.995 | 0.45 | 1.48 | 3.1 | 87 ± 9 | 113 ± 5 | 119 ± 3 |
| 25I-NBF | 0.995 | 0.67 | 2.09 | 4.2 | 95 ± 9 | 110 ± 3 | 118 ± 2 |
| 25E-NBOMe | 0.994 | 0.41 | 1.36 | 2.9 | 95 ± 10 | 109 ± 4 | 119 ± 3 |
| 25I-NBOMe | 0.994 | 0.97 | 3.22 | 7.0 | 90 ± 9 | 110 ± 1 | 121 ± 5 |
| 25P-NBOMe | 0.993 | 0.30 | 0.99 | 2.1 | 108 ± 2 | 88 ± 9 | 104 ± 9 |
| 25T4-NBOMe | 0.993 | 0.40 | 1.34 | 3.0 | 110 ± 3 | 90 ± 5 | 110 ± 8 |
LOD limit of detection, LOQ limit of quantification, RSD relative standard deviation