Fig. 1.

The Main TTFL of the circadian clock regulation and the effect of resveratrol BMAL1/CLOCK heterodimer binds to E-box element of target genes, such as Per2 and Cry, which are negative clock components. Once expressed, they inhibit BMAL1 and CLOCK expression. Resveratrol induces SIRT1, which deacetylases BMAL1 resulting in the enhancement of its activity. SIRT1 was also shown to deacetylate PER2 leading to its degradation