Fig. 4.

In vivo innate immune activity in rhesus macaques. A Outline for toxicity and safety study in rhesus macaques administered 1 mg/kg i.v., 0.1 mg/kg i.v., or 0.1 mg/kg s.c. (n = 2 per group). B Levels of MAB273 in plasma over time (left), AUC (area under curve, right) is calculated after normalizing (left) to linear axes. n = 2 per group. C–E Surface expression levels of CD40 (C), costimulatory marker CD80 and LN homing marker CCR7 on B cells (D) and MDCs (E) were evaluated by flow cytometry over time. n = 2 per group. F Systemic levels of pro-inflammatory cytokines (IL-12 p40, IL-6, IFN-γ) in plasma over time. n = 2 per group