Fig. 7.

MAB273 can potentiate induction of antigen-specific CD4 T cells and CD8 T cells in PBMCs and BAL. A In the therapeutic vaccination group, rhesus macaques (n = 3) were administered 0.1 mg/kg s.c. of Env peptides for the first two immunizations then 1 mg/kg Env peptides plus 0.1 mg/kg MAB273 s.c. for the last immunization; in the prophylactic vaccination group, rhesus macaques (n = 3) were co-injected with 0.1 mg/kg Env peptides plus 0.1 mg/kg MAB273 s.c. for the first two immunizations then 1 mg/kg Env peptides plus 0.1 mg/kg MAB273 s.c. for the third immunization, followed 1 mg/kg Env peptides, 0.1 mg/kg MAB273 plus 100 μg Env protein for the last immunization. B Antigen-specific CD4 T cells and CD8 T cells in PBMCs and BAL in therapeutic vaccination group. n = 3. C Antigen-specific CD4 T cells and CD8 T cells in PBMCs and BAL in prophylactic vaccination group. n = 3