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. 2023 Apr 11;41(3):380–390. doi: 10.1007/s10637-022-01326-3

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — (a) Arithmetic mean plasma concentration versus time curves for MK-8353 following oral administration of the combination, (b) arithmetic mean plasma concentration versus time curves for selumetinib following oral administration of the combination, (c) arithmetic mean plasma concentration versus time curves for desmethyl selumetinib following oral administration of the combination, and (d) ¹⁸F-fluoro-deoxy-glucose positron emission tomography (FDG-PET) results in patients treated at a cycle 1, day 1 dose of MK-8353 100 mg + selumetinib 50 mg, MK-8353 150 mg + selumetinib 75 mg, and in patients where the dose reduction occurred before cycle 2, day 4 PET scans. CFB, change from baseline; SD, standard deviation; SUV, standardized uptake value